What is Freiberg’s Disease? Freiberg’s Disease (also known as Freiberg’s Infraction) is a type of osteochondroses that most commonly affects the second Metatarsal bone in the foot. Your Metatarsals are a group of 5 bones that are located in the mid-foot and are connected to your toe bones. Freiberg’s Disease is often associated with Metatarsalgia. ...